How to explane sepsis neotal app in a conference


Is there a scoring system for neonatal sepsis?

More recently, scoring systems have been developed in an attempt to predict the risk of neonatal sepsis, guide management and reduce unnecessary antibiotic exposure. Currently, the most commonly used is the Kaiser Permanente Neonatal Early-Onset Sepsis Calculator.

What is the most commonly used sepsis calculator?

Currently, the most commonly used is the Kaiser Permanente Neonatal Early-Onset Sepsis Calculator.

What is being done to improve the SIRS – sepsis criteria?

Investigators are continuing to refine the SIRS – Sepsis criteria and make them more clinically useful. The current approach has involved the use of various biomarkers to facilitate the identification of patients with a high likelihood of bacterial infection and/or high risk for morbidity and mortality.

What causes sepsis in newborns?

1 Neonatal sepsis is caused by bacterial, viral or fungal infection. 2 It is classified as either early-onset (<48-72 hours) or late-onset (>48-72 hours) sepsis. 3 The presentation can be non-specific, so diagnosis requires a high index of suspicion. More items…


How do you explain sepsis to a patient?

Sepsis is the body’s extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Infections that lead to sepsis most often start in the lung, urinary tract, skin, or gastrointestinal tract.

How do you approach neonatal sepsis?

The condition of a neonate with true sepsis can deteriorate quickly, thus the most common approach is to initiate empiric broad-spectrum antibiotic therapy in all young infants with suspected bacterial infection [49]. A negative blood culture after 48 hours may allow cessation of antibiotic therapy in a well infant.

What does neonatal sepsis mean?

Neonatal sepsis is a blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.

How is neonatal sepsis classified?

Neonatal sepsis may be divided into two types: early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS). EONS is typically described as infection and sepsis occurring within the first 24 hours to first week of life [1–3].

What is neonatal sepsis management?

Empirical treatment for neonatal sepsis, recommended in current WHO guidelines is intravenous ampicillin (or penicillin) plus gentamicin for 7 days. Cloxacillin is an alternative if Staphylococcal infection is suspected.

What is the main form of presentation in early onset neonatal sepsis?

General symptoms include lethargy, hypothermia, and poor feeding, and nonspecific signs may include anuria and acidosis. As pneumonia is often the presenting infection, respiratory symptoms are common and may include apnea, tachypnea, grunting, nasal flaring, and intercostal retractions.

What is neonatal sepsis PDF?

Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life. It encompasses various systemic infections of the newborn such as septicemia, meningitis, pneumonia, arthritis, osteomyelitis, and urinary tract infections.

What is the pathophysiology of neonatal sepsis?

Mainly caused by ascending infection in the mother with chorioamnionitis, perinatally via direct contact in the birth canal and haematogenous spread. The main micro-organisms associated with EONS include; GBS, E- coli, Coagulase-negative Staphylococcus, H influenzae and Listeria monocytogenes (4).

What are the risk factors of neonatal sepsis?

Gestational age, infection of the genitourinary tract and premature rupture of fetal membranes were the main gestational risk factors involved in neonatal sepsis.

What is the conclusion of neonatal sepsis?

Conclusion. In conclusion, manifestations of neonatal sepsis are non-specific. A high index of suspicion with or without lab evidences of infection is the key for early diagnosis. Prompt institution of antibiotic therapy and supportive care will save most of the cases of neonatal sepsis.

What is neonatal sepsis Wikipedia?

Neonatal sepsis is a type of neonatal infection and specifically refers to the presence in a newborn baby of a bacterial blood stream infection (BSI) (such as meningitis, pneumonia, pyelonephritis, or gastroenteritis) in the setting of fever.

What is the leading cause of neonatal sepsis and death?

Among children, the most common causes of sepsis-related deaths were neonatal disorders, lower respiratory infections, and diarrhoeal diseases (1). Group B streptococcus is the leading cause of both neonatal and maternal sepsis, though Escherichia coli is an emerging threat (8,9).

How is neonatal infection treated?

Ampicillin and gentamicin remains the cornerstone of initial antimicrobial regimen for early-onset neonatal infections. The combination of such broad-spectrum antibiotic regimens cover the most common cause (GBS and E coli in more than 70%)1 of EOS and has synergistic activity (against GBS and Listeria monocytogenes).

When should you suspect neonatal sepsis?

Signs and symptoms of neonatal sepsis can range from nonspecific or vague symptoms to hemodynamic collapse. Early symptoms may include irritability, lethargy, or poor feeding. Others may quickly develop respiratory distress, fever, hypothermia or hypotension with poor perfusion and shock.

How can you prevent a neonatal infection?

How can I help my baby avoid infections?Wash your hands thoroughly. Washing your hands often is really important in the fight against infections. … Use disposable tissues. … Keep your baby’s environment clean. … Avoid people who are unwell. … Go smoke free. … Look, don’t touch.

When should you suspect sepsis in a newborn?

In contrast to older infants, children and adults, the signs of sepsis in the newborn are vague and nonspecific. The earliest signs may be apnea, respiratory distress or poor feeding. Other signs and symptoms include lethargy, temperature instability, hyperbilirubinemia, bradycardia, seizures and acidosis.


Aetiology and Risk Factors 1,2

Clinical Features

Differential Diagnoses

Investigations 4,6

Management 4,6

Prognosis and Complications 7

Key Points

  1. Neonatal sepsis is caused by bacterial, viral or fungal infection.
  2. It is classified as either early-onset (<48-72 hours) or late-onset(>48-72 hours) sepsis.
  3. The presentation can be non-specific, so diagnosis requires a high index of suspicion.
  4. Key investigations include a septic screen(blood, CSF and urine cultures, FBC and CRP) with further investigations for specific concerns.

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